Important to know: Scientific researches about medicinal properties of hydrogen

The medicinal properties of molecular hydrogen appear to be promoted as early as 1798. Many years later in 1975,  the departments of Biology and Chemistry from the prestigious Baylor University and Texas A&M published a great article on the potential use of molecular hydrogen in medicine in the premier peer-reviewed journal of Science. However, it wasn’t until 2007, when an article was published in Nature MedicinePrior to 2007, only 50 articles were published regarding hydrogen as a medical gas, compared to over 500 articles within the past seven years.  Perhaps the main reason why it is only recently that molecular hydrogen is being recognized as a therapeutic molecule is because of scientific skepticism. It is difficult to believe diatomic molecular hydrogen could have any therapeutic effects because it is generally considered to be an inert gas.


(Click on links below to read more information).


Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals


Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes


Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model

Hydrogen-rich electrolyzed warm water represses wrinkle formation

Effects of hydrogen-rich water on aging periodontal tissues in rats

Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells

Hydrogen atoms in protein structures: high-resolution X-ray diffraction structure of the DFPase

Obesity and Diabetes:

Molecular Hydrogen Improves Obesity and Diabetes

Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation

Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Lepr cp/NDmcr rat kidney

Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells

Lactulose: an effective preventive and therapeutic option for ischemic stroke by production of hydrogen


Electrolyzed–Reduced Water Scavenges Active Oxygen Species and Protects DNA from Oxidative Damage


Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury

Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study

Hydrogen is neuroprotective against surgically induced brain injury

Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits

Bipolar disorder and schizophrenia:

Molecular hydrogen: an overview of its neurobiological effects and therapeutic potential for bipolar disorder and schizophrenia


Hyperbaric hydrogen therapy: a possible treatment for cancer

Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors

Gastric problems:

Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water

Rheumatoid arthritis:

Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study

Inflammatory diseases:

Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies

Parkinson’s disease:

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats

A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics

Other diseases:

A review of experimental studies of hydrogen as a new therapeutic agent in emergency and critical care medicine

Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Lepr cp/NDmcr rat – a metabolic syndrome rat model

A hypothesis on chemical mechanism of the effect of hydrogen


Progress in the study of biological effects of hydrogen on higher plants and its promising application in agriculture

Medical Molecular Hydrogen Research Meeting:

Medical Molecular Hydrogen Symposium: An inaugural symposium of the journal “Medical Gas Research

Hydrogen determination in water:

A convenient method for determining the concentration of hydrogen in water: use of methylene blue with colloidal platinum




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